Published in
Royal Society of Chemistry, Chemical Science, 8(12), p. 2898-2908, 2021
DOI: 10.1039/d0sc05172a
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2-Mercaptomethyl-thiazolidines use conserved aromatic-S interactions to achieve broad-range inhibition of metallo-β-lactamases
Journal article published in 2021 by
Maria-Agustina Rossi 
,
Veronica Martinez ,
Philip Hinchliffe ,
Maria-Fernanda Mojica ,
Valerie Castillo,
Diego Martín Moreno ,
Ryan Smith,
Brad Spellberg,
George L. Drusano,
Claudia Banchio,
Robert A. Bonomo,
James Spencer ,
Alejandro J. Vila ,
Graciela Mahler
,
Veronica Martinez ,
Philip Hinchliffe ,
Maria-Fernanda Mojica ,
Valerie Castillo,
Diego Martín Moreno ,
Ryan Smith,
Brad Spellberg,
George L. Drusano,
Claudia Banchio,
Robert A. Bonomo,
James Spencer ,
Alejandro J. Vila ,
Graciela Mahler
This paper is made freely available by the publisher.
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Abstract
Metallo-β-lactamases (MBLs) are major culprits of resistance to carbapenems in bacteria. A series of thiazolidines are potent MBL inhibitors, restoring the activity of carbapenems. Metal binding and sulphur–π interactions are key to inhibition.