Published in
Wiley, European Journal of Inorganic Chemistry, 22(2010), p. 3513-3519, 2010
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Click Chelators – The Behavior of Platinum and Palladium Complexes in the Presence of Guanosine and DNA
Journal article published in 2010 by
Aurélien Chevry,
Marie-Laure Teyssot,
Aurélie Maisonial,
Pascale Lemoine,
Bernard Viossat,
Mounir Traikia,
David J. Aitken,
Georges Alves,
Laurent Morel,
Lionel Nauton,
Arnaud Gautier
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Abstract
Triazole chelators, synthesized by click chemistry, are convenient ligands for palladium(II) and platinum(II). Conformational changes induced by the complexation of these PdII and PtII complexes with guanosine are similar to those of cisplatin. In addition, these complexes behave like cisplatin with regard to the relaxation of supercoiled plasmid DNA