Escherichia coli Genomic Diversity within Extraintestinal Acute Infections Argues for Adaptive Evolution at Play
Journal article published in 2021 by
Antoine Bridier-Nahmias 
,
Adrien Launay,
Alexandre Bleibtreu,
Mélanie Magnan,
Violaine Walewski,
Jérémie Chatel,
Sara Dion,
Véronique Robbe-Saule,
Olivier Clermont,
Françoise Norel,
Erick Denamur,
Olivier Tenaillon
,
Adrien Launay,
Alexandre Bleibtreu,
Mélanie Magnan,
Violaine Walewski,
Jérémie Chatel,
Sara Dion,
Véronique Robbe-Saule,
Olivier Clermont,
Françoise Norel,
Erick Denamur,
Olivier Tenaillon
This paper is made freely available by the publisher.
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Abstract
Little is known about the dynamics of adaptation in acute bacterial infections. By sequencing multiple isolates from monoclonal extraintestinal Escherichia coli infections in several patients, we were able to uncover traces of selection taking place at short time scales compared to chronic infection.