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Elsevier, Bioorganic and Medicinal Chemistry Letters, 7(19), p. 2029-2032, 2009

DOI: 10.1016/j.bmcl.2009.02.027

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Adjuvant properties of a simplified C32 monomycolyl glycerol analogue

Journal article published in 2009 by Veemal Bhowruth, David E. Minnikin, Else Marie Agger, Peter Andersen, Vincent W. Bramwell, Yvonne Perrie, Gurdyal S. Besra ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

A simplified C32 monomycolyl glycerol (MMG) analogue demonstrated enhanced immunostimulatory activity in a dioctadecyl ammonium bromide (DDA)/Ag85B-ESAT-6 formulation. Elevated levels of IFN-gamma and IL-6 were produced in spleen cells from mice immunised with a C32 MMG analogue comparable activity to the potent Th1 adjuvant, trehalose 6,6'-di-behenate (TDB).