Significance Carbon redox chemistry plays a fundamental role in biology. However, the thermodynamic and physicochemical principles underlying the rise of metabolites involved in redox biochemistry remain poorly understood. Our work introduces the theory and techniques that allow us to quantify and understand the global energy landscape of carbon redox biochemistry. We analyze the space of all possible oxidation states of linear-chain molecules with two to five carbon atoms and generate a detailed atlas of the thermodynamic stability of metabolites in comparison to nonbiological molecules. Although the emergence of life required the underlying chemistry to bootstrap itself out of equilibrium, a quantitative understanding of the environment-dependent thermodynamic landscape of prebiotic molecules will be extremely valuable for future origins of life models.