Published in
American Society for Microbiology, Journal of Virology, 6(95), 2021
DOI: 10.1128/jvi.01986-20
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Sequence evaluation and comparative analysis of novel assays for intact proviral HIV-1 DNA
Journal article published in 2020 by
Christian Gaebler 
,
Shane D. Falcinelli ,
Elina Stoffel,
Jenna Read,
Ross Murtagh,
Thiago Y. Oliveira,
Victor Ramos,
Julio C. C. Lorenzi,
Jennifer Kirchherr,
Katherine S. James,
Brigitte Allard,
Caroline Baker,
JoAnn D. Kuruc,
Marina Caskey,
Nancie M. Archin
and other authors.
,
Shane D. Falcinelli ,
Elina Stoffel,
Jenna Read,
Ross Murtagh,
Thiago Y. Oliveira,
Victor Ramos,
Julio C. C. Lorenzi,
Jennifer Kirchherr,
Katherine S. James,
Brigitte Allard,
Caroline Baker,
JoAnn D. Kuruc,
Marina Caskey,
Nancie M. Archin
and other authors.
This paper is made freely available by the publisher.
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Abstract
The intact proviral DNA assay (IPDA) and quadruplex PCR (Q4PCR) represent major advances in accurately quantifying and characterizing the replication-competent HIV reservoir. This study compares the two novel approaches for measuring intact HIV proviral DNA in samples from 39 antiretroviral therapy (ART)-suppressed people living with HIV, thereby informing ongoing efforts to deplete the HIV reservoir in cure-related trials.