BACKGROUND: Musculoskeletal disorders (MSDs) are prevalent among waste collectors (WCs) in developing countries. AIM: This study aimed to investigate the prevalence of MSDs and the factors associated with the risk of persistent musculoskeletal pain among WCs in Hanoi, Vietnam. METHODS: A cross-sectional survey was utilized to study 468 WCs in 2017. The Örebro Musculoskeletal Pain Questionnaire and a questionnaire on demographic and work conditions were used to collect data. Descriptive and multivariate logistics regression analyzes were applied at a significance level of 0.05 to examine the factors related to the risk of persistent pain. FINDINGS: About 74.4% of the participants of this study experienced MSDs in at least one body region and 9.4% reported MSDs in all 10 body sites. The lower back was reported to be the most affected followed by the neck and shoulders. The risk of persistent musculoskeletal pain was significantly associated with age (odds ratio (OR) = 2.31, confidence interval (CI) = 1.05–5.09), gender (OR = 3.29, CI = 1.28–8.44), work hours (OR = 2.35, CI = 1.12–4.92), work shift (OR = 0.48, CI = 0.26–0.92), duration of poor postures of the neck (OR = 0.31, CI = 0.13–0.76), bent back (OR = 0.4 CI = 0.18–0.92) and for medial rotation (OR = 3.01, CI = 1.42–6.36), carrying heavy objects (OR = 2.94, CI = 1.15–7.48), and experience of work dissatisfaction (OR = 3.31, CI = 1.46-7.52), stress (OR = 7.14, CI = 3.14–16.24), or anxiety (OR = 6.37, CI = 3.07–13.21). CONCLUSIONS: High prevalence of MSDs among WCs and its association with self-assessed unfavorable work postures and work-related stress implies the need of mechanical and social support at work for WC to prevent the development of MSDs and persistent pain.