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Royal Society of Chemistry, Chemical Science, 3(12), p. 880-895, 2021

DOI: 10.1039/d0sc03175e

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Engineering mono- and multi-valent inhibitors on a modular scaffold

Journal article published in 2021 by Aurora Diamante, Piyush K. Chaturbedy, Pamela J. E. Rowling, Janet R. Kumita ORCID, Rohan S. Eapen ORCID, Stephen H. McLaughlin, Marc de la Roche, Albert Perez-Riba ORCID, Laura S. Itzhaki ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We exploit the simple modular architecture of repeat proteins to create a platform for single- and multi-functional display in diverse programmable geometries and demonstrate proof of concept by building potent inhibitors of a key signalling pathway.