Published in

American Society for Microbiology, Journal of Virology, 5(95), 2021

DOI: 10.1128/jvi.01785-20

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Suberoyl bis-hydroxamic acid reactivates Kaposi’s sarcoma-associated herpesvirus through histone acetylation and induces apoptosis in lymphoma cells

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Kaposi’s sarcoma and primary effusion lymphoma cells are latently infected with Kaposi’s sarcoma-associated herpesvirus (KSHV), whereas KSHV replication is frequently observed in multicentric Castleman disease. Although KSHV replication can be induced by some chemical reagents (e.g., 12-O-tetradecanoylphorbol-13-acetate), the mechanism of KSHV replication is not fully understood.