Dissemin is shutting down on January 1st, 2025

Published in

National Academy of Sciences, Proceedings of the National Academy of Sciences, 52(117), p. 33570-33577, 2020

DOI: 10.1073/pnas.2009093117

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Uncovering the genetic blueprint of the C. elegans nervous system

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Preprint: archiving forbidden
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Postprint: archiving allowed
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Data provided by SHERPA/RoMEO

Abstract

Significance A fundamental question of neuroscience is how the brain wires itself. Here, we propose a modeling framework that explains how cellular connectivity emerges from neuronal identity, allowing us to offer experimentally falsifiable predictions on the genetic encoding of the connectome. The rapid advances in brain science require quantitative frameworks to integrate genetic and connectome information. The proposed model responds to this need, helping us unveil the genetically driven mechanisms that govern the formation of individual links in the brain.