Nutritional status has been linked to clinical outcomes in patients with cancer, and those being treated with haematopoietic stem cell transplant (HSCT) have a significant potential for prolonged periods of poor oral nutrition. This article explores factors affecting the provision of timely nasogastric tube feeding. A preliminary literature search identified a growing evidence-base for the choice and timing of nutritional support therapy. However, existing evidence and personal experience suggest that the use of nasogastric tubes to feed patients is often resisted by both health professionals and patients. This is the first systematic review to explore factors affecting attitudes on the decision to commence nasogastric tube feeding. Wide variation in practice already exists. Therefore, a better understanding of factors that affect the attitudes of health professionals and patients towards nutritional support therapy can facilitate the delivery of optimal nutritional care. The results provide a new perspective on how to achieve the best possible outcomes for patients.