Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 3(65), 2021
DOI: 10.1128/aac.01945-20
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The Pharmacodynamic-Toxicodynamic Relationship of AUC and C <sub>max</sub> in Vancomycin-Induced Kidney Injury in an Animal Model
Journal article published in 2021 by
Sean N. Avedissian,
Gwendolyn Pais 
,
Jiajun Liu ,
J. Nicholas O’Donnell ,
Thomas P. Lodise ,
Michael Neely,
Walter C. Prozialeck,
Peter C. Lamar,
Leighton Becher,
Marc H. Scheetz
,
Jiajun Liu ,
J. Nicholas O’Donnell ,
Thomas P. Lodise ,
Michael Neely,
Walter C. Prozialeck,
Peter C. Lamar,
Leighton Becher,
Marc H. Scheetz
This paper is made freely available by the publisher.
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Abstract
Vancomycin induces exposure-related acute kidney injury. However, the pharmacokinetic-toxicodynamic (PK-TD) relationship remains unclear.