<b><i>Background:</i></b> COVID-19 is a respiratory disease transmitted through respiratory droplets and has a high transmission rate. There is still no effective and approved antiretroviral treatment or vaccine, so preventative measures remain the key to contain this pandemic. Portugal is now in phase 3.2 of the mitigation of COVID-19, with it being imperative to understand the health literacy of our country and prevent a lack of information through community empowerment. <b><i>Material and Methods:</i></b> A cross-sectional study with a sample from a primary care facility was conducted. We collected demographic and epidemiological data and carried out a questionnaire by phone call. Descriptive statistics and nonparametric tests were used to assess associations between the independent variables and the level of health literacy. The level of significance was set at <i>p</i> &#x3c; 0.05. <b><i>Results:</i></b> Our sample included 222 subjects (median age 62 years), mostly females (<i>n</i> = 131), undergraduates (<i>n</i> = 193), and with at least 1 risk factor for COVID-19 (<i>n</i> = 144). Overall, younger individuals, females, graduates and the nonrisk group appeared to have higher levels of health literacy, with some exceptions. <b><i>Conclusions:</i></b> We observed a well-informed population. However, it being a pandemic situation, our intention was to identify and correct outliers/misconceptions. This work allowed a perspective of the current state/pattern of health literacy as well as its possible predictors. Furthermore, it raised awareness of the relevance of specific communication approaches. Further studies to understand the predictors of health literacy are necessary.