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Springer, Archives of Virology, 2(166), p. 639-643, 2020

DOI: 10.1007/s00705-020-04895-x

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Full genome sequence of bovine alphaherpesvirus 2 (BoHV-2)

Journal article published in 2020 by Florian Pfaff ORCID, Antonie Neubauer-Juric ORCID, Stefan Krebs ORCID, Andreas Hauser ORCID, Stefanie Singer, Helmut Blum ORCID, Bernd Hoffmann ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

AbstractWe present the complete genome sequence of bovine alphaherpesvirus 2 (BoHV-2), a member of the family Herpesviridae, subfamily Alphaherpesvirinae, genus Simplexvirus. BoHV-2 is the causative agent of bovine ulcerative mammillitis (bovine herpes mammillitis) and pseudo-lumpy skin disease. The genomic architecture of BoHV-2 is typical of most simplexvirus genomes and congruent with that of human alphaherpesvirus 1 (HHV-1). The genome comprises a total of 131,245 base pairs and has an overall G+C content of 64.9 mol%. A total of 75 open reading frames are predicted. The gene repertoire of BoHV-2 is analogous to that of HHV-1, although the coding region of US12 is missing. A phylogenetic analysis supported BoHV-2 as a member of the genus Simplexvirus.