Plant grafting, the ancient practice of cutting and joining different plants, is gaining popularity as an elegant way to generate chimeras that combine desirable traits. Grafting was originally developed in woody species, but the technique has evolved over the past century to now encompass a large number of herbaceous species. The use of plant grafting in science is accelerating in part due to the innovative techniques developed for the model plantArabidopsis thaliana. Here, we review these developments and discuss the advantages and limitations associated with grafting variousArabidopsistissues at diverse developmental stages.