Published in
National Academy of Sciences, Proceedings of the National Academy of Sciences, 51(117), p. 32574-32583, 2020
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TCRα reporter mice reveal contribution of dual TCRα expression to T cell repertoire and function
Journal article published in 2020 by
Letitia Yang,
Burhan Jama,
Huawei Wang 
,
Lara Labarta-Bajo ,
Elina I. Zúñiga,
Gerald P. Morris
,
Lara Labarta-Bajo ,
Elina I. Zúñiga,
Gerald P. Morris
This paper is made freely available by the publisher.
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Abstract
Significance This study utilizes novel transgenic reporter mice to definitively evaluate T cells coexpressing two T cell antigen receptors. These experiments demonstrate that T lymphocytes naturally coexpressing two different antigen receptors are significantly more abundant than previous estimates and that these cells have a previously unappreciated role in physiologic immune responses.