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American Physiological Society, AJP - Endocrinology and Metabolism, 2(320), p. E359-E378, 2021

DOI: 10.1152/ajpendo.00352.2020

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Thermogenic recruitment of brown and brite/beige adipose tissues is not obligatorily associated with macrophage accretion or attrition

Journal article published in 2020 by Nathalie Boulet ORCID, Ineke H. N. Luijten, Barbara Cannon, Jan Nedergaard
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

A regulatory or mediatory role—positive or negative—for macrophages in the recruitment of brown adipose tissue is presently discussed. As the recruited state in the tissue is a dynamic process, maintenance of the recruited state would need persistent alterations in macrophage complement. Contrary to this expectation, we demonstrate here an absence of alterations in macrophage complement in thermogenically recruited brown—or brite/beige—adipose tissues. Macrophage regulation of thermogenic capacity is thus less likely.