Abstract COVID-19 is the most recently discovered coronavirus infectious disease and leads to pandemic all over the world. The clinical continuum of COVID-19 varies from mild illness with non-specific signs and symptoms of acute respiratory disease to extreme respiratory pneumonia and septic shock. It can transmit from animal to human in the form of touch, through the air, water, utensils, fomite and feco-oral route blood. The pathogenesis and clinical features of COVID-19 be the same as the clinical manifestation associated epidemic Fever. In Unani medicine, various herbal drugs are described under the caption of epidemic disease. Great Unani scholar also Avicenna (980–1037 AD) recommended that during epidemic condition movement should be restricted, self-isolation, fumigation around the habitant with perfumed herbs (Ood, Kafoor, Sumbuluttib, Saad Kofi, Loban, etc.), and use of appropriate antidotes (Tiryaqe Wabai) and vinegar (Sirka) as prophylaxis. Herbal approach is based on single (Unnab—Ziziphus jujuba, Sapistan—Cordia myxa, Bahidana—Cydonia oblonga, Khatmi—Althea officinalis, Khubazi—Malva sylvestris, Zafran—Crocus sativus, Sibr—Aloe barbedensis, Murmuki—Commiphora myrrha, Darchini—Cinnamomum zeylanicum, Qaranfal—Syzygium aromaticum, Rihan—Oscimum sanctum, Habtus Sauda—Nigella sativa, Aslus Sus—Glycyrrhiza glabra, Maghze Amaltas—Cassia fistula and Adusa—Adhatoda vasica) and compound drugs (Habbe Bukhar, Sharbat Khaksi, Sharbat Zanjabeel, Naqu Nazla, Majoon Chobchini, Jawrish Jalinus and Khamira Marvareed) most of them are claimed for anti-viral, anti-pyretic, blood purifier, cardioprotective and expectorant activities. Traditionally most of the herbal practitioners are using it.