Published in
National Academy of Sciences, Proceedings of the National Academy of Sciences, 51(117), p. 32215-32222, 2020
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Striking heterogeneity of somatic L1 retrotransposition in single normal and cancerous gastrointestinal cells
Journal article published in 2020 by
Katsumi Yamaguchi,
Alisha O. Soares,
Loyal A. Goff,
Anjali Talasila,
Jungbin A. Choi,
Daria Ivenitsky,
Sadik Karma 
,
Benjamin Brophy,
Scott E. Devine,
Stephen J. Meltzer ,
Haig H. Kazazian
,
Benjamin Brophy,
Scott E. Devine,
Stephen J. Meltzer ,
Haig H. Kazazian
This paper is made freely available by the publisher.
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Abstract
Significance Using a modified method, we analyzed single cells from adenocarcinomas of the colon, pancreas, and stomach and their paired normal tissues for somatic LINE-1 retrotransposition events. We found that somatic retrotransposition varied significantly from patient to patient with cancers of the same type, as well as in different cells within a particular cancer.