Published in
Nature Research, npj Parkinson's Disease, 1(6), 2020
DOI: 10.1038/s41531-020-00140-z
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Cerebrospinal fluid glutamate changes in functional movement disorders
Journal article published in 2020 by
Benedetta Demartini 
,
Roberto William Invernizzi,
Laura Campiglio,
Tommaso Bocci,
Andrea D’Arrigo,
Andrea Arighi ,
Francesca Sciacca ,
Daniela Galimberti ,
Elio Scarpini,
Orsola Gambini,
Alberto Priori
,
Roberto William Invernizzi,
Laura Campiglio,
Tommaso Bocci,
Andrea D’Arrigo,
Andrea Arighi ,
Francesca Sciacca ,
Daniela Galimberti ,
Elio Scarpini,
Orsola Gambini,
Alberto Priori
This paper is made freely available by the publisher.
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Abstract
AbstractThe aim of this study was to assess cerebrospinal fluid (CSF) concentrations of specific amino acids using a high-performance liquid chromatography system in a sample of patients with functional movement disorders (FMDs) and in a sample of controls. CSF levels of glutamate were significantly lower in patients with FMD than in controls. This finding argues in favor of glutamatergic dysfunction in the pathophysiology of FMD.