Significance Continuous monitoring of cerebral hemodynamics is critical for safeguarding the healthy neurodevelopment of pediatric patients. This paper introduces a soft, flexible, miniaturized wireless system for real-time, continuous monitoring of systemic and cerebral hemodynamics for such purposes. Clinical studies on pediatric subjects with ages between 0.2 and 15 y and with various racial backgrounds validate opportunities for practical use in operating hospital environments. This platform may significantly enhance the quality of care of pediatric patients, particularly those at risk for cerebral and neurodevelopmental impairments in developed and developing world settings alike.