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Wiley, Angewandte Chemie International Edition, 29(52), p. 7432-7436, 2013

DOI: 10.1002/anie.201301567

Wiley, Angewandte Chemie, 29(125), p. 7580-7584, 2013

DOI: 10.1002/ange.201301567

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Repair of the (6-4) Photoproduct by DNA Photolyase Requires Two Photons

Journal article published in 2013 by Junpei Yamamoto, Ryan Martin, Shigenori Iwai, Pascal Plaza, Klaus Brettel
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Single-turnover flash experiments showed that the flavoenzyme (6-4) photolyase uses a successive two-photon mechanism to repair the UV-induced T(6-4)T lesion in DNA (see picture). The intermediate (X) formed by the first photoreaction is likely to be the oxetane-bridged dimer T(ox)T. The enzyme could stabilize the normally short-lived T(ox)T, allowing repair to be completed by the second photoreaction.