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Royal Society of Chemistry, Chemical Science, 4(12), p. 1479-1485, 2021

DOI: 10.1039/d0sc05725h

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Regiodivergent Synthesis of Pyrazino-Indolines vs. Triazocines via α-Imino Carbenes Addition to Imidazolidines

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Hexahydropyrazinoindoles are prepared in a single step from N-sulfonyl triazoles and imidazolidines. Of mechanistic importance, a regiodivergent reactivity can be engineered towards the exclusive formation of 8-membered ring 1,3,6-triazocines.