Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial

Ramasamy, Maheshi N.; Minassian, Angela M.; Ewer, Katie J.; Flaxman, Amy L.; Folegatti, Pedro M.; Owens, Daniel R.; Voysey, Merryn; Aley, Parvinder K.; Angus, Brian; Fedosyuk, Sofiyah; Babbage, Gavin; Belij-Rammerstorfer, Sandra; Bibi, Sagida; Berry, Lisa; Bittaye, Mustapha; Cathie, Katrina; Chappell, Harry; Charlton, Sue; Cicconi, Paola; Clutterbuck, Elizabeth A.; Colin-Jones, Rachel; Dold, Christina; Emary, Katherine R. W.; Fuskova, Michelle; Gbesemete, Diane; Green, Catherine; Hallis, Bassam; Hou, Mimi M.; Jenkin, Daniel; Joe, Carina C. D.; Kelly, Elizabeth J.; Kerridge, Simon; Lawrie, Alison M.; Lelliott, Alice; Mn, Ramasamy; Lwin, May N.; Makinson, Rebecca; Marchevsky, Natalie G.; Mujadidi, Yama; Munro, Alasdair P. S.; Pacurar, Mihaela; Plested, Emma; Rand, Jade; Rawlinson, Thomas; Rhead, Sarah; Robinson, Hannah; Ritchie, Adam J.; Ross-Russell, Amy L.; Saich, Stephen; Singh, Nisha; Smith, Catherine C.; Snape, Matthew D.; Song, Rinn; Tarrant, Richard; Themistocleous, Yrene; Thomas, Kelly M.; Villafana, Tonya L.; Warren, Sarah C.; Watson, Marion E. E.; Douglas, Alexander D.; Hill, Adrian V. S.; Lambe, Teresa; Gilbert, Sarah C.; Faust, Saul N.; Pollard, Andrew J.; Aboagye, Jeremy; Adams, Kelly; Ali, Aabidah; Allen, Elizabeth R.; Am, Minassian; Allen, Lauren; Allison, Jennifer L.; Andritsou, Foteini; Anslow, Rachel; Arbe-Barnes, Edward H.; Baker, Megan; Baker, Natalie; Baker, Philip; Baleanu, Ioana; Barker, Debbie; Barnes, Eleanor; Barrett, Jordan R.; Barrett, Kelly; Bates, Louise; Batten, Alexander; Beadon, Kirsten; Beckley, Rebecca; Bellamy, Duncan; Berg, Adam; Bermejo, Laura; Berrie, Eleanor; Beveridge, Amy; Bewley, Kevin R.; Bijker, Else M.; Birch, Geeta; Blackwell, Luke; Bletchly, Heather; Blundell, Caitlin L.; Kj, Ewer; Blundell, Susannah R.; Bolam, Emma; Boland, Elena; Bormans, Daan; Borthwick, Nicola; Boukas, Konstantinos; Bower, Thomas; Bowring, Francesca; Boyd, Amy; Brenner, Tanja; Brown, Phillip; Brown-O'Sullivan, Charlie; Bruce, Scott; Brunt, Emily; Burbage, Jamie; Burgoyne, Joshua; Buttigieg, Karen R.; Byard, Nicholas; Cabera Puig, Ingrid; Puig, I. C.; Camara, Susana; Cao, Michelangelo; Cappuccini, Federica; Carr, Melanie; Carroll, Miles W.; Cashen, Paul; Cavey, Ana; Chadwick, Jim; Challis, Ruth; Chapman, David; Charles, David; Chelysheva, Irina; Cho, Jee-Sun; Cifuentes, Liliana; Clark, Elizabeth; Collins, Sarah; Conlon, Christopher P.; Coombes, Naomi S.; Cooper, Rachel; Cooper, Cushla; Crocker, Wendy E. M.; Al, Flaxman; Crosbie, Sarah; Cullen, Dan; Cunningham, Christina J.; Cuthbertson, Fiona; Datoo, Brad E.; Dando, Lynne; Datoo, Mehreen S.; Datta, Chandrabali; Davies, Hannah; Davies, Sarah; Damratoski, B. E.; Davis, Elizabeth J.; Davis, Judith; Dearlove, David; Demissie, Tesfaye; Di Marco, Stefania; Di Maso, Claudio; DiTirro, Danielle; Docksey, Claire; Dong, Tao; Donnellan, Francesca R.; Douglas, Naomi; Downing, Charlotte; Drake, Jonathan; Drake-Brockman, Rachael; Drury, Ruth E.; Dunachie, Susanna J.; Edwards, Christopher J.; Edwards, Nick J.; El Muhanna, Omar; Elias, Sean C.; Elliott, Ryan S.; Elmore, Michael J.; English, Marcus Rex; Pm, Folegatti; Felle, Sally; Feng, Shuo; Ferreira Da Silva, Carla; Field, Samantha; Fisher, Richard; Fixmer, Carine; Ford, Karen J.; Fowler, Jamie; Francis, Emma; Frater, John; Furze, Julie; Galian-Rubio, Pablo; Galloway, Celine; Garlant, Harriet; Gavrila, Madita; Gibbons, Felicity; Gibbons, Karyna; Gilbride, Ciaran; Gill, Hardeep; Godwin, Kerry; Gordon-Quayle, Katherine; Gorini, Giacomo; Goulston, Lyndsey; Grabau, Caroline; Gracie, Lara; Graham, Nichola; Greenwood, Nicola; Griffiths, Oliver; Gupta, Gaurav; Hamilton, Elizabeth; Hanumunthadu, Brama; Harris, Stephanie A.; Harris, Tara; Hanumanthadu, B.; Harrison, Daisy; Hart, Thomas C.; Dr, Owens; Hartnell, Birgit; Haskell, Louise; Hawkins, Sophia; Henry, John Aaron; Hill, David; Hill, Jennifer; Hodges, Gina; Hodgson, Susanne H. C.; Horton, Katie L.; Howe, Elizabeth; Howell, Nicola; Howes, Jessica; Huang, Ben; Humphreys, Jonathan; Humphries, Holly E.; Iveson, Poppy; Jackson, Frederic; Jackson, Susan; Jauregui, Sam; Herrera, M. H.; Jeffers, Helen; Jones, Bryony; Jones, Christine E.; Jones, Elizabeth; Jones, Kathryn; Joshi, Amar; Kailath, Reshma; Keen, Jade; Kelly, Dearbhla M.; Kelly, Sarah; Kelly, Debbie M.; Kerr, David; Khan, Liaquat; Khozoee, Baktash; Killen, Annabel; Kinch, Jasmin; King, Lloyd D. W.; King, Thomas B.; Kingham, Lucy; Klenerman, Paul; Knight, Julian C.; Knott, Daniel; Koleva, Stanislava; Lang, Gail; Larkworthy, Colin W.; Larwood, Jessica P. J.; Law, Rebecca L.; Lee, Arlene; Lee, Kim Y. N.; Lees, Emily A.; Leung, Stephanie; Li, Yuanyuan; Lias, Amelia M.; Linder, Aline; Lipworth, Samuel; Liu, Shuchang; Liu, Xinxue; Lloyd, Stephanie; Loew, Lisa; Lopez Ramon, Raquel; Madhavan, Meera; Mainwaring, David O.; Mallett, Garry; Mansatta, Kushal; Marinou, Spyridoula; Pk, Aley; Marius, Phedra; Marlow, Emma; Marriott, Paula; Marshall, Julia L.; Martin, Jane; Masters, Shauna; McEwan, Joanne; McGlashan, Joanna L.; McInroy, Lorna; McRobert, Nicky; Megson, Clare; Morris, Susan J.; Mentzer, Alexander J.; Mirtorabi, Neginsadat; Mitton, Celia; Moore, Maria; Moran, Marni; Morey, Ella; Morgans, Róisín; Morrison, Hazel Morrison; Morshead, Gertraud; Morter, Richard; Moya, Nathifa A.; Mukhopadhyay, Ekta; Muller, Jilly; Munro, Claire; Morris, S. R.; Murphy, Sarah; Mweu, Philomena; Noé, Andrés; Nugent, Fay L.; O'Brien, Katie; O'Connor, Daniel; Oguti, Blanché; Olchawski, Victoria; Oliveira, Catarina; Parsons, Karen; O'Reilly, Peter John; Osborne, Piper; Owen, Lydia; Owino, Nelly; Papageorgiou, Panagiotis; Parracho, Helena; Parsons, K.; Patel, Bhumika; Patrick-Smith, Maia; Peng, Yanchun; Penn, Elizabeth J.; Peralta Alvarez, Marco Polo; Perring, James; Petropoulos, Christos; Phillips, Daniel J.; Pipini, Dimitra; Pollard, Samuel; Oliveria, C.; Poulton, Ian; Pratt, Danny; Presland, Laura; Proud, Pamela C.; Provstgaard-Morys, Samuel; Pueschel, Sophie; Pulido, David; Rabara, Ria; Radia, Kajal; Rajapaska, Durga; Ramos Lopez, Fernando; Ratcliffe, Helen; Rayhan, Sara; Rees, Byron; Parsons, H.; Reyes Pabon, Emilia; Roberts, Hannah; Robertson, Isla; Roche, Sophie; Rollier, Christine S.; Romani, Rossana; Rose, Zoe; Rudiansyah, Indra; Sabheha, Sabeha; Salvador, Stephannie; Sanders, Helen; Sanders, Katherine; Satti, Iman; Sayce, Chloe; Schmid, Annina B.; Schofield, Ella; Screaton, Gavin; Sedik, Cynthia; Seddiqi, Samiullah; Segireddy, Rameswara R.; Rajapaksa, D.; Selby, Beatrice; Shaik, Imam; Sharpe, Hannah R.; Shaw, Robert; Shea, Adam; Silk, Sarah; Silva-Reyes, Laura; Skelly, Donal T.; Smith, David J.; Smith, Daniel C.; Pabon, E.; Smith, Nicholas; Spencer, Alexandra J.; Spoors, Louise; Stafford, Elizabeth; Stamford, Imogen; Stockdale, Lisa; Stockley, David; Stockwell, Lisa V.; Stokes, Matthew; Strickland, Louise H.; Stuart, Arabella; Sulaiman, Sulaiman; Summerton, Eloise; Swash, Zoe; Szigeti, Anna; Tahiri-Alaoui, Abdessamad; Tanner, Rachel; Taylor, Iona J.; te Water Naude, Rebecca; Taylor, Keja; Taylor, Ursula; Themistocleous, Andreas; Thomas, Merin; Thomas, Tonia M.; Thompson, Amber; Thompson, Kevin; Thornton-Jones, Viv; Tinh, Lan; Tomic, Adriana; Tonks, Susan; Towner, James; Tran, Nguyen; Tree, Julian A.; Truby, Adam; Turner, Cheryl; Turner, Richard; Walker, Laura; Ulaszewska, Marta; Wand, Matthew E.; Varughese, Rachel; Watkins, Bridget; Verbart, Dennis; Welch, Jessica; Verheul, Marije K.; Vichos, Iason; West, Alison J.; White, Caroline; White, Rachel; Williams, Paul; Woodyer, Mark; Worth, Andrew T.; Wright, Daniel; Wrin, Terri; Yao, Xin Li; Zbarcea, Diana-Andreea; Alaoui, A.; Zizi, Dalila; Group, Oxford Covid Vaccine Trial

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Dr Angela M. Minassian
Ramasamy et al., 2020

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Elsevier, The Lancet, 10267(396), p. 1979-1993, 2020

DOI: 10.1016/s0140-6736(20)32466-1

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@article{Ramasamy2020,
  author = {Ramasamy, Maheshi N. and Minassian, Angela M. and Ewer, Katie J. and Flaxman, Amy L. and Folegatti, Pedro M. and Owens, Daniel R. and Voysey, Merryn and Aley, Parvinder K. and Angus, Brian and Fedosyuk, Sofiyah and Babbage, Gavin and Belij-Rammerstorfer, Sandra and Bibi, Sagida and Berry, Lisa and Bittaye, Mustapha and Cathie, Katrina and Chappell, Harry and Charlton, Sue and Cicconi, Paola and Clutterbuck, Elizabeth A. and Colin-Jones, Rachel and Dold, Christina and Emary, Katherine R. W. and Fuskova, Michelle and Gbesemete, Diane and Green, Catherine and Hallis, Bassam and Hou, Mimi M. and Jenkin, Daniel and Joe, Carina C. D. and Kelly, Elizabeth J. and Kerridge, Simon and Lawrie, Alison M. and Lelliott, Alice and Mn, Ramasamy and Lwin, May N. and Makinson, Rebecca and Marchevsky, Natalie G. and Mujadidi, Yama and Munro, Alasdair P. S. and Pacurar, Mihaela and Plested, Emma and Rand, Jade and Rawlinson, Thomas and Rhead, Sarah and Robinson, Hannah and Ritchie, Adam J. and Ross-Russell, Amy L. and Saich, Stephen and Singh, Nisha and Smith, Catherine C. and Snape, Matthew D. and Song, Rinn and Tarrant, Richard and Themistocleous, Yrene and Thomas, Kelly M. and Villafana, Tonya L. and Warren, Sarah C. and Watson, Marion E. E. and Douglas, Alexander D. and Hill, Adrian V. S. and Lambe, Teresa and Gilbert, Sarah C. and Faust, Saul N. and Pollard, Andrew J. and Aboagye, Jeremy and Adams, Kelly and Ali, Aabidah and Allen, Elizabeth R. and Am, Minassian and Allen, Lauren and Allison, Jennifer L. and Andritsou, Foteini and Anslow, Rachel and Arbe-Barnes, Edward H. and Baker, Megan and Baker, Natalie and Baker, Philip and Baleanu, Ioana and Barker, Debbie and Barnes, Eleanor and Barrett, Jordan R. and Barrett, Kelly and Bates, Louise and Batten, Alexander and Beadon, Kirsten and Beckley, Rebecca and Bellamy, Duncan and Berg, Adam and Bermejo, Laura and Berrie, Eleanor and Beveridge, Amy and Bewley, Kevin R. and Bijker, Else M. and Birch, Geeta and Blackwell, Luke and Bletchly, Heather and Blundell, Caitlin L. and Kj, Ewer and Blundell, Susannah R. and Bolam, Emma and Boland, Elena and Bormans, Daan and Borthwick, Nicola and Boukas, Konstantinos and Bower, Thomas and Bowring, Francesca and Boyd, Amy and Brenner, Tanja and Brown, Phillip and Brown-O'Sullivan, Charlie and Bruce, Scott and Brunt, Emily and Burbage, Jamie and Burgoyne, Joshua and Buttigieg, Karen R. and Byard, Nicholas and Cabera Puig, Ingrid and Puig, I. C. and Camara, Susana and Cao, Michelangelo and Cappuccini, Federica and Carr, Melanie and Carroll, Miles W. and Cashen, Paul and Cavey, Ana and Chadwick, Jim and Challis, Ruth and Chapman, David and Charles, David and Chelysheva, Irina and Cho, Jee-Sun and Cifuentes, Liliana and Clark, Elizabeth and Collins, Sarah and Conlon, Christopher P. and Coombes, Naomi S. and Cooper, Rachel and Cooper, Cushla and Crocker, Wendy E. M. and Al, Flaxman and Crosbie, Sarah and Cullen, Dan and Cunningham, Christina J. and Cuthbertson, Fiona and Datoo, Brad E. and Dando, Lynne and Datoo, Mehreen S. and Datta, Chandrabali and Davies, Hannah and Davies, Sarah and Damratoski, B. E. and Davis, Elizabeth J. and Davis, Judith and Dearlove, David and Demissie, Tesfaye and Di Marco, Stefania and Di Maso, Claudio and DiTirro, Danielle and Docksey, Claire and Dong, Tao and Donnellan, Francesca R. and Douglas, Naomi and Downing, Charlotte and Drake, Jonathan and Drake-Brockman, Rachael and Drury, Ruth E. and Dunachie, Susanna J. and Edwards, Christopher J. and Edwards, Nick J. and El Muhanna, Omar and Elias, Sean C. and Elliott, Ryan S. and Elmore, Michael J. and English, Marcus Rex and Pm, Folegatti and Felle, Sally and Feng, Shuo and Ferreira Da Silva, Carla and Field, Samantha and Fisher, Richard and Fixmer, Carine and Ford, Karen J. and Fowler, Jamie and Francis, Emma and Frater, John and Furze, Julie and Galian-Rubio, Pablo and Galloway, Celine and Garlant, Harriet and Gavrila, Madita and Gibbons, Felicity and Gibbons, Karyna and Gilbride, Ciaran and Gill, Hardeep and Godwin, Kerry and Gordon-Quayle, Katherine and Gorini, Giacomo and Goulston, Lyndsey and Grabau, Caroline and Gracie, Lara and Graham, Nichola and Greenwood, Nicola and Griffiths, Oliver and Gupta, Gaurav and Hamilton, Elizabeth and Hanumunthadu, Brama and Harris, Stephanie A. and Harris, Tara and Hanumanthadu, B. and Harrison, Daisy and Hart, Thomas C. and Dr, Owens and Hartnell, Birgit and Haskell, Louise and Hawkins, Sophia and Henry, John Aaron and Hill, David and Hill, Jennifer and Hodges, Gina and Hodgson, Susanne H. C. and Horton, Katie L. and Howe, Elizabeth and Howell, Nicola and Howes, Jessica and Huang, Ben and Humphreys, Jonathan and Humphries, Holly E. and Iveson, Poppy and Jackson, Frederic and Jackson, Susan and Jauregui, Sam and Herrera, M. H. and Jeffers, Helen and Jones, Bryony and Jones, Christine E. and Jones, Elizabeth and Jones, Kathryn and Joshi, Amar and Kailath, Reshma and Keen, Jade and Kelly, Dearbhla M. and Kelly, Sarah and Kelly, Debbie M. and Kerr, David and Khan, Liaquat and Khozoee, Baktash and Killen, Annabel and Kinch, Jasmin and King, Lloyd D. W. and King, Thomas B. and Kingham, Lucy and Klenerman, Paul and Knight, Julian C. and Knott, Daniel and Koleva, Stanislava and Lang, Gail and Larkworthy, Colin W. and Larwood, Jessica P. J. and Law, Rebecca L. and Lee, Arlene and Lee, Kim Y. N. and Lees, Emily A. and Leung, Stephanie and Li, Yuanyuan and Lias, Amelia M. and Linder, Aline and Lipworth, Samuel and Liu, Shuchang and Liu, Xinxue and Lloyd, Stephanie and Loew, Lisa and Lopez Ramon, Raquel and Madhavan, Meera and Mainwaring, David O. and Mallett, Garry and Mansatta, Kushal and Marinou, Spyridoula and Pk, Aley and Marius, Phedra and Marlow, Emma and Marriott, Paula and Marshall, Julia L. and Martin, Jane and Masters, Shauna and McEwan, Joanne and McGlashan, Joanna L. and McInroy, Lorna and McRobert, Nicky and Megson, Clare and Morris, Susan J. and Mentzer, Alexander J. and Mirtorabi, Neginsadat and Mitton, Celia and Moore, Maria and Moran, Marni and Morey, Ella and Morgans, Róisín and Morrison, Hazel Morrison and Morshead, Gertraud and Morter, Richard and Moya, Nathifa A. and Mukhopadhyay, Ekta and Muller, Jilly and Munro, Claire and Morris, S. R. and Murphy, Sarah and Mweu, Philomena and Noé, Andrés and Nugent, Fay L. and O'Brien, Katie and O'Connor, Daniel and Oguti, Blanché and Olchawski, Victoria and Oliveira, Catarina and Parsons, Karen and O'Reilly, Peter John and Osborne, Piper and Owen, Lydia and Owino, Nelly and Papageorgiou, Panagiotis and Parracho, Helena and Parsons, K. and Patel, Bhumika and Patrick-Smith, Maia and Peng, Yanchun and Penn, Elizabeth J. and Peralta Alvarez, Marco Polo and Perring, James and Petropoulos, Christos and Phillips, Daniel J. and Pipini, Dimitra and Pollard, Samuel and Oliveria, C. and Poulton, Ian and Pratt, Danny and Presland, Laura and Proud, Pamela C. and Provstgaard-Morys, Samuel and Pueschel, Sophie and Pulido, David and Rabara, Ria and Radia, Kajal and Rajapaska, Durga and Ramos Lopez, Fernando and Ratcliffe, Helen and Rayhan, Sara and Rees, Byron and Parsons, H. and Reyes Pabon, Emilia and Roberts, Hannah and Robertson, Isla and Roche, Sophie and Rollier, Christine S. and Romani, Rossana and Rose, Zoe and Rudiansyah, Indra and Sabheha, Sabeha and Salvador, Stephannie and Sanders, Helen and Sanders, Katherine and Satti, Iman and Sayce, Chloe and Schmid, Annina B. and Schofield, Ella and Screaton, Gavin and Sedik, Cynthia and Seddiqi, Samiullah and Segireddy, Rameswara R. and Rajapaksa, D. and Selby, Beatrice and Shaik, Imam and Sharpe, Hannah R. and Shaw, Robert and Shea, Adam and Silk, Sarah and Silva-Reyes, Laura and Skelly, Donal T. and Smith, David J. and Smith, Daniel C. and Pabon, E. and Smith, Nicholas and Spencer, Alexandra J. and Spoors, Louise and Stafford, Elizabeth and Stamford, Imogen and Stockdale, Lisa and Stockley, David and Stockwell, Lisa V. and Stokes, Matthew and Strickland, Louise H. and Stuart, Arabella and Sulaiman, Sulaiman and Summerton, Eloise and Swash, Zoe and Szigeti, Anna and Tahiri-Alaoui, Abdessamad and Tanner, Rachel and Taylor, Iona J. and te Water Naude, Rebecca and Taylor, Keja and Taylor, Ursula and Themistocleous, Andreas and Thomas, Merin and Thomas, Tonia M. and Thompson, Amber and Thompson, Kevin and Thornton-Jones, Viv and Tinh, Lan and Tomic, Adriana and Tonks, Susan and Towner, James and Tran, Nguyen and Tree, Julian A. and Truby, Adam and Turner, Cheryl and Turner, Richard and Walker, Laura and Ulaszewska, Marta and Wand, Matthew E. and Varughese, Rachel and Watkins, Bridget and Verbart, Dennis and Welch, Jessica and Verheul, Marije K. and Vichos, Iason and West, Alison J. and White, Caroline and White, Rachel and Williams, Paul and Woodyer, Mark and Worth, Andrew T. and Wright, Daniel and Wrin, Terri and Yao, Xin Li and Zbarcea, Diana-Andreea and Alaoui, A. and Zizi, Dalila and Group, Oxford Covid Vaccine Trial},
  doi = {10.1016/s0140-6736(20)32466-1},
  journal = {The Lancet},
  month = {nov},
  pages = {1979-1993},
  title = {Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial},
  url = {https://oadoi.org/10.1016/s0140-6736(20)32466-1},
  volume = {396},
  year = {2020}
}

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