Published in
American Association for the Advancement of Science, Science Translational Medicine, 570(12), 2020
DOI: 10.1126/scitranslmed.aaz5327
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Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis
Journal article published in 2020 by
Hendy Kristyanto 
,
Nienke J. Blomberg,
Linda M. Slot,
Ellen I. H. van der Voort,
Priscilla F. Kerkman ,
Aleida Bakker,
Leonie E. Burgers,
Robin M. ten Brinck ,
Annette H. M. van der Helm-Van Mil,
Hergen Spits ,
Dominique L. Baeten,
Tom W. J. Huizinga ,
René E. M. Toes ,
Hans U. Scherer
,
Nienke J. Blomberg,
Linda M. Slot,
Ellen I. H. van der Voort,
Priscilla F. Kerkman ,
Aleida Bakker,
Leonie E. Burgers,
Robin M. ten Brinck ,
Annette H. M. van der Helm-Van Mil,
Hergen Spits ,
Dominique L. Baeten,
Tom W. J. Huizinga ,
René E. M. Toes ,
Hans U. Scherer
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Abstract
Proliferative autoreactive B cells secreting proinflammatory cytokines are associated with early, untreated RA and persist in established disease.