Published in
American Association for the Advancement of Science, Science Advances, 47(6), 2020
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Caspase-8–dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality
Journal article published in 2020 by
Benjamin Demarco 
,
James P. Grayczyk ,
Elisabet Bjanes,
Didier Le Roy ,
Wulf Tonnus ,
Charles-Antoine Assenmacher ,
Enrico Radaelli ,
Timothée Fettrelet ,
Vanessa Mack ,
Andreas Linkermann ,
Thierry Roger ,
Igor E. Brodsky ,
Kaiwen W. Chen ,
Petr Broz
,
James P. Grayczyk ,
Elisabet Bjanes,
Didier Le Roy ,
Wulf Tonnus ,
Charles-Antoine Assenmacher ,
Enrico Radaelli ,
Timothée Fettrelet ,
Vanessa Mack ,
Andreas Linkermann ,
Thierry Roger ,
Igor E. Brodsky ,
Kaiwen W. Chen ,
Petr Broz
This paper is made freely available by the publisher.
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Abstract
Caspase-8–dependent GSDMD activation promotes antibacterial defense; however, this pathway can also mediate TNF shock in vivo.