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Early immune response patterns to pathogenic bacteria are associated to increased risk of lower respiratory infections in children

Journal article published in 2014 by Nh H. Vissing, Jeppe Madura Larsen, Mette Annelie Rasmussen ORCID, Anna Hammerich Thysen, Bl L. Chawes, K. Bønnelykke, Susanne Brix Pedersen, Hans Flinker Bisgaard
This paper was not found in any repository; the policy of its publisher is unknown or unclear.
This paper was not found in any repository; the policy of its publisher is unknown or unclear.

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Abstract

Neonatal colonisation of the airways with respiratory pathogens is associated with increased risk of lower respiratory infections (LRI) in early childhood (1). Therefore, we hypothesized that children developing LRI have an abnormal immune response to pathogenic bacteria in infancy. We aimed to characterise the systemic immune response to pathogenic bacteria at the age of 6 months and study the association with incidence of LRI during the first 3 years of life.