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American Physiological Society, American Journal of Physiology - Gastrointestinal and Liver Physiology, 2(320), p. G206-G216, 2021

DOI: 10.1152/ajpgi.00313.2020

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Eosinophil-associated micro-inflammation in the gastroduodenal tract contributes to gastric hypersensitivity in a rat model of early life adversity

Journal article published in 2020 by Shaoqi Duan, Takashi Kondo, Hiroto Miwa, Yanjing Yang, Shenglan Wang, Hirosato Kanda, Yoko Kogure, Nobuko Imamura, Tadahiro Fujimura, Tomoaki Kono, Masashi Fukushima, Katsuyuki Tozawa, Toshihiko Tomita, Tadayuki Oshima ORCID, Hirokazu Fukui and other authors.
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

We showed for the first time that neonatal MS stress-induced FD rats undergo gastroduodenal eosinophil-associated microinflammation in adulthood. Suppression of microinflammation attenuated gastric hypersensitivity in MS rats. These findings established a functional link between microinflammation and gastric hypersensitivity, which may provide a potential clue for the clinical treatment of FD.