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National Academy of Sciences, Proceedings of the National Academy of Sciences, 45(117), p. 28307-28315, 2020

DOI: 10.1073/pnas.2016997117

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The adaptor protein APPL2 controls glucose-stimulated insulin secretion via F-actin remodeling in pancreatic β-cells

Journal article published in 2020 by Baile Wang ORCID, Huige Lin ORCID, Xiaomu Li ORCID, Wenqi Lu, Jae Bum Kim, Aimin Xu ORCID, Kenneth K. Y. Cheng ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Significance Dysregulation of cytoskeletal remodeling could result in defective GSIS and cause type 2 diabetes. Previous studies have reported the role of small GTPases including Rac1 and Cdc42 in the regulation of F-actin remodeling, whereas the upstream regulatory pathway remains poorly understood. Here, we identify the adaptor protein APPL2 as an upstream regulator of Rac1 activation. APPL2 promotes F-actin remodeling by antagonizing the inhibitory effect of RacGAP1 on Rac1 activation, which eventually enhances GSIS. Our findings fill the overall puzzle of F-actin remodeling with a crucial piece and provide insights into type 2 diabetes with disrupted actin dynamics.