Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 2(65), 2021
DOI: 10.1128/aac.01383-20
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Pharmacokinetics of Benznidazole in Experimental Chronic Chagas Disease Using the Swiss mouse-Berenice-78 Trypanosoma cruzi Strain Model
Journal article published in 2020 by
Suzana Marques de Jesus,
Leonardo Pinto 
,
Fernanda de Lima Moreira ,
Glauco Henrique Balthazar Nardotto ,
Rodrigo Cristofoletti,
Luísa Perin,
Kátia da Silva Fonseca,
Pauliana Barbêdo,
Lorena Cera Bandeira,
Paula Melo de Abreu Vieira,
Claudia Martins Carneiro
,
Fernanda de Lima Moreira ,
Glauco Henrique Balthazar Nardotto ,
Rodrigo Cristofoletti,
Luísa Perin,
Kátia da Silva Fonseca,
Pauliana Barbêdo,
Lorena Cera Bandeira,
Paula Melo de Abreu Vieira,
Claudia Martins Carneiro
This paper is made freely available by the publisher.
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Abstract
Chronic Chagas disease might have an impact on benznidazole pharmacokinetics with potential alterations in the therapeutic dosing regimen. This study aims to investigate the influence of chronic Trypanosoma cruzi infection on the pharmacokinetics and biodistribution of benznidazole in mice.