The results of a national survey conducted by the National Narcotics Agency (BNN) in collaboration with the Center for Research on Pranata, University of Indonesia, showed the prevalence of drug-psychotropic abuse among junior, high school and tertiary students in 30 provincial capitals in 2013 by 3.4%. Trends in the number of abusers among adolescents show an increase every year. Until 2013 the number of drug abusers among adolescents increased 3x from 2009.. This study was conducted to determine the direct and indirect factors affecting drug abuse in teen age. The study used mix methode qualitative and quantitative study method through univariate analysis. The study population consisted of family and teen’s drug abuser, and a sample of 40 of them was taken. The measurement results of univariate analysis Statistics on the influence of variables in the structural model and overall variables showed a positive and significant effect. The T-statistic value of all variables was above the critical value (1.96). The results of the test indicated that the empowerment and social support variables, directly and indirectly, influenced factors abilities. Knowledge, perceptions, attitudes and parenting had impacts directly on the factors abilities. Knowledge, family support, perceptions, attitudes and parenting variables had an influence on drug abuse abilities of teen. A controlled trial study should be done to see the impact of this model on reducing the risks during rehabilitation.