Objective: explore qualitative research on the meanings of living with a chronic wound. Method: it is a qualitative meta-synthesis. 13 articles were included, totaling a sample of 248 individuals who self-reported living with a chronic wound. The Critical Appraisal Skills Program instrument was used to evaluate the eligible articles, and to report the qualitative synthesis, the recommendations of Enhancing transparency in reporting the synthesis of qualitative research were followed. The analysis and extraction of information and construction of the synthesis were carried out by two independent reviewers, with the assistance of a third expert reviewer. Results: living with a chronic wound involves initial concerns and the appearance of symptoms, especially marked pain. They report that the increase in pain led to low functional capacity, as well as weakened social relationships and financial conditions. The experiences illustrate the challenges of emotional burden and the implications of illness, which contributed to social isolation. Religiosity and spirituality were the main coping strategies. Conclusion: living with a chronic wound means a condition of pain, limits physical and functional capacity, causes negative feelings and emotions that result in people’s isolation.