A sediment core from a Mediterranean karstic lake was studied through its pollen, diatom, chydorid, ostracod, charcoal and authigenic mineral composition. Information about environmental history recorded in the sediment sequence since the Middle Ages is presented. The main fluctuations of water volume and trophic status of the lake occurred during periods of great change in land management and during climatic cold phases. The synergetic effect of these two factors led to a high water level phase and triggered a rising of the trophic level which produced meromixis. The onset of meromictic conditions at about 1700 AD coincides with the Maunder minimum in the Little Ice Age as well as with a period of increasing human population, woodland clearance and agricultural expansion to the detriment of the nomadic livestock-breeding or transhumance ("Mesta").