Flash flooding is considered one of the most dynamic natural disasters for which measures need to be taken to minimize economic damages, adverse effects, and consequences by mapping flood susceptibility. Identifying areas prone to flash flooding is a crucial step in flash flood hazard management. In the present study, the Kalvan watershed in Markazi Province, Iran, was chosen to evaluate the flash flood susceptibility modeling. Thus, to detect flash flood-prone zones in this study area, five machine learning (ML) algorithms were tested. These included boosted regression tree (BRT), random forest (RF), parallel random forest (PRF), regularized random forest (RRF), and extremely randomized trees (ERT). Fifteen climatic and geo-environmental variables were used as inputs of the flash flood susceptibility models. The results showed that ERT was the most optimal model with an area under curve (AUC) value of 0.82. The rest of the models’ AUC values, i.e., RRF, PRF, RF, and BRT, were 0.80, 0.79, 0.78, and 0.75, respectively. In the ERT model, the areal coverage for very high to moderate flash flood susceptible area was 582.56 km2 (28.33%), and the rest of the portion was associated with very low to low susceptibility zones. It is concluded that topographical and hydrological parameters, e.g., altitude, slope, rainfall, and the river’s distance, were the most effective parameters. The results of this study will play a vital role in the planning and implementation of flood mitigation strategies in the region.