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Future Medicine, Epigenomics, 19(12), p. 1689-1706, 2020

DOI: 10.2217/epi-2020-0127

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Association of HERV-K and LINE-1 hypomethylation with reduced disease-free survival in melanoma patients

Journal article published in 2020 by Maurizio Cardelli ORCID, Remco van Doorn ORCID, Lares Larcher, Michela Di Donato, Francesco Piacenza ORCID, Elisa Pierpaoli ORCID, Robertina Giacconi ORCID, Marco Malavolta ORCID, Sivaramakrishna Rachakonda ORCID, Nelleke A. Gruis ORCID, Anders Molven ORCID, Per Arne Andresen, Dace Pjanova ORCID, Joost J. van den Oord, Mauro Provinciali ORCID and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Aim: To evaluate CpG methylation of long interspersed nuclear elements 1 (LINE-1) and human endogenous retrovirus K (HERV-K) retroelements as potential prognostic biomarkers in cutaneous melanoma. Materials & methods: Methylation of HERV-K and LINE-1 retroelements was assessed in resected melanoma tissues from 82 patients ranging in age from 14 to 88 years. In addition, nevi from eight patients were included for comparison with nonmalignant melanocytic lesions. Results: Methylation levels were lower in melanomas than in nevi. HERV-K and LINE-1 methylation were decreased in melanoma patients with clinical parameters associated with adverse prognosis, while they were independent of age and gender. Hypomethylation of HERV-K (but not LINE-1) was an independent predictor of reduced disease-free survival. Conclusion: HERV-K hypomethylation can be a potential independent biomarker of melanoma recurrence.