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Wiley, FEBS Letters, 8(585), p. 1191-1196, 2011

DOI: 10.1016/j.febslet.2011.03.039

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miR-126 inhibits proliferation of small cell lung cancer cells by targeting SLC7A5

Journal article published in 2011 by Mikó Edit (1980-) (biológus), Margitai Zoltán, Edit Miko, Zsolt Czimmerer, Czimmerer Zsolt (1981-) (Ph D. Hallgató), Várkonyi Ildikó (szakorvos Jelölt), Ildikó Várkonyi, Dezső Balázs (1951-) (pathológus), Balázs Dezso, Arpád Lányi, Immunológus) Lányi Árpád (1962-) (biológus, Bacsó Zsolt (1963-) (biofizikus), Zsolt Bacsó, Molekuláris Biológus) Scholtz Beáta (1967-) (biokémikus ORCID
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Abstract

Despite intensive efforts to improve therapies, small cell lung cancer (SCLC) still has a dismal median survival of 18 months. Since miR-126 is under-expressed in the majority of SCLC tumors, we investigated the effect of miR-126 overexpression on the proliferation and cell cycle distribution of H69 cells. Our results demonstrate that miR-126 inhibits proliferation of H69 cells, by delaying the cells in the G1 phase. Short interfering RNA (siRNA) mediated suppression of SLC7A5, a predicted target of mir-126, has the same effect on H69 cells. We also show for the first time that SLC7A5 is a direct target of miR-126.