Published in
Bentham Science Publishers, Current HIV Research: HIV and Viral Immune Diseases, 2(19), p. 188-194, 2021
DOI: 10.2174/1570162x18666201026143200
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The identification of a novel HIV-1 second-generation recombinant form (CRF01_AE/CRF07_BC) among men who have sex with men in Jiangsu, China
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Zhou Ying ,
Lu Jing ,
Guo Hongxiong,
Chen Jianshuang,
Xuan Yan,
Cheng Hao,
Yuan Defu,
Hu Haiyang,
Xu Xiaoqin,
Wang Bei,
Fu Gengfeng
Full text: Unavailable
Abstract
Background: CRF01_AE and CRF07_BC are the two major HIV-1 virus strains circulating in China. The proportion of dominant subtypes (CRF01_AE and CRF07_BC) among MSM in Jiangsu province was over 80%. A large number of URFs have been found in China in recent years. Objective: This study aimed to report on novel HIV-1 recombinants. Method: We constructed Phylogenetic trees using the maximum likelihood (ML) method with 1000 bootstrap replicates in IQ-TREE 1.6.8 software and determined recombination breakpoints using SimPlot 3.5.1. Results: We identified a novel, second-generation HIV-1 recombinant (JS020202) between CRF01_ AE and CRF07_BC. The analysis of near full-length genome (NFLG) showed there were at least 8 breakpoints in the virus, which differed from any previously identified CRF and URF around the world. Conclusion: Novel diverse CRF01_AE/07_BC suggested the complexity trends of HIV-1 genetics. The emergency situation of diverse recombinant strains should be monitored continuously.