The COVID-19 pandemic is bringing about changes, and alongside these, we can alter the way we design our living spaces. The need for a healthy and comfortable living space is essential to mental and physical well-being. The present study covers the most up-to-date documents, including peer-reviewed papers, blog posts, news, journal articles, and expert opinions, to critically review lessons learned from the COVID-19 pandemic and evaluates the expected changes in sustainability requirements of residential buildings. Health and safety, environment, and comfort are the three main aspects of residential buildings that have been tested during quarantines and are also expected to experience major transformations toward sustainability. Residential houses should provide certain health and safety protective measures to their occupants, such as the application of new touchless technologies, having proper sanitation to diminish the probability of getting infected, and developing greener and more intimate spaces that can help recover and improve mental states. Our findings address the need to reconsider sustainability requirements for residential buildings, which will provide adequate health and safety and comfort with no significant harm to the environment.