Published in
American Association for the Advancement of Science, Science Immunology, 52(5), 2020
DOI: 10.1126/sciimmunol.abc1884
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Itaconate controls the severity of pulmonary fibrosis
Journal article published in 2020 by
Patricia P. Ogger 
,
Gesa J. Albers ,
Richard J. Hewitt ,
Brendan J. O’Sullivan ,
Joseph E. Powell ,
Emily Calamita ,
Poonam Ghai,
Simone A. Walker,
Peter McErlean ,
Peter Saunders ,
Shaun Kingston ,
Philip L. Molyneaux ,
John M. Halket ,
Robert Gray ,
Daniel C. Chambers
and other authors.
,
Gesa J. Albers ,
Richard J. Hewitt ,
Brendan J. O’Sullivan ,
Joseph E. Powell ,
Emily Calamita ,
Poonam Ghai,
Simone A. Walker,
Peter McErlean ,
Peter Saunders ,
Shaun Kingston ,
Philip L. Molyneaux ,
John M. Halket ,
Robert Gray ,
Daniel C. Chambers
and other authors.
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Abstract
The ACOD1/itaconate axis is a pulmonary regulatory pathway that controls the severity of fibrosis and is a potential therapeutic target in IPF.