Published in
Brazilian Journal of Analytical Chemistry, (8), 2020
DOI: 10.30744/brjac.2179-3425.rv-27-2020
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Key information related to quality by design (QbD) applications in analytical methods development
Journal article published in 2020 by
Alisson Silva Araújo 
,
Daniel Fernandes Andrade ,
Diego Victor Babos ,
Jeyne Pricylla Castro ,
José Augusto Garcia ,
Marco Aurelio Sperança ,
Raimundo Rafael Gamela ,
Raquel Cardoso Machado ,
Vinícius Câmara Costa ,
Wesley Nascimento Guedes ,
Edenir Rodrigues Pereira-Filho ,
Fabíola Manhas Verbi Pereira
,
Daniel Fernandes Andrade ,
Diego Victor Babos ,
Jeyne Pricylla Castro ,
José Augusto Garcia ,
Marco Aurelio Sperança ,
Raimundo Rafael Gamela ,
Raquel Cardoso Machado ,
Vinícius Câmara Costa ,
Wesley Nascimento Guedes ,
Edenir Rodrigues Pereira-Filho ,
Fabíola Manhas Verbi Pereira
Abstract
In this review, quality by design (QbD) initiatives are described as applications for many types of processes, such as in the pharmaceutical industry, biotechnology field, and for analytical methods development. Design space (DS) and design of experiments (DoE) provide useful results for analytical methods development and simulation of advanced processes in traditional manufacturing relationships. The three topics, QbD, DS and DoE are the best way to achieve strong and efficient industrial production.