Published in
Royal Society of Chemistry, Chemical Science, 43(11), p. 11720-11728, 2020
DOI: 10.1039/d0sc03828h
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Selective inhibition of the K+ efflux sensitive NLRP3 pathway by Cl− channel modulation
Journal article published in 2020 by
Tessa Swanton 
,
James A. Beswick ,
Halah Hammadi,
Lucy Morris,
Daniel Williams,
Stephane de Cesco,
Lina El-Sharkawy,
Shi Yu,
Jack Green ,
John B. Davis,
Catherine B. Lawrence,
David Brough ,
Sally Freeman
,
James A. Beswick ,
Halah Hammadi,
Lucy Morris,
Daniel Williams,
Stephane de Cesco,
Lina El-Sharkawy,
Shi Yu,
Jack Green ,
John B. Davis,
Catherine B. Lawrence,
David Brough ,
Sally Freeman
This paper is made freely available by the publisher.
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Abstract
The NLRP3 inflammasome regulates production of the pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18, and contributes to inflammation exacerbating disease.