Published in
Nature Research, Nature Communications, 1(11), 2020
DOI: 10.1038/s41467-020-19146-5
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Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein
Journal article published in 2020 by
Antoni G. Wrobel 
,
Donald J. Benton ,
Saira Hussain ,
Ruth Harvey,
Stephen R. Martin,
Chloë Roustan,
Peter B. Rosenthal ,
John J. Skehel,
Steven J. Gamblin
,
Donald J. Benton ,
Saira Hussain ,
Ruth Harvey,
Stephen R. Martin,
Chloë Roustan,
Peter B. Rosenthal ,
John J. Skehel,
Steven J. Gamblin
This paper is made freely available by the publisher.
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Abstract
AbstractThe CR3022 antibody, selected from a group of SARS-CoV monoclonal antibodies for its ability to cross-react with SARS-CoV-2, has been examined for its ability to bind to the ectodomain of the SARS-CoV-2 spike glycoprotein. Using cryo-electron microscopy we show that antibody binding requires rearrangements in the S1 domain that result in dissociation of the spike.