Context: Cognitive disorders are one of the most common neurological problems that can be caused by lifestyle patterns, especially sedentary lifestyle, poor nutrition, exposure to a variety of toxins or diseases. Evidence Acquisition: There are various strategies recommended for the prevention and treatment of these disorders, including drug therapy, psychological therapy, dietary pattern changes, and physical activity. Results: It seems that physical activity with biological mechanisms can have beneficial effects on the central nervous system and improve cognitive function, including enhanced learning and memory, as well as reduced depression and anxiety. Conclusions: Of the major mechanisms that physical activity can affect cognitive function include increased neurogenic factors, decreased oxidative stress, decreased inflammatory mediators, and mitochondrial biogenesis. Therefore, it is recommended that people with cognitive impairments can use physical activity as an appropriate strategy to prevent and treat cognitive impairment problems.