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IUPHAR/BPS Guide to Pharmacology CITE, 4(2020), 2020

DOI: 10.2218/gtopdb/f34/2020.4

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Kisspeptin receptor (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database

Journal article published in 2020 by Anthony P. Davenport ORCID, Janet J. Maguire ORCID, Edward J. Mead, Adam J. Pawson ORCID
This paper was not found in any repository; the policy of its publisher is unknown or unclear.
This paper was not found in any repository; the policy of its publisher is unknown or unclear.

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Abstract

The kisspeptin receptor (nomenclature as agreed by the NC-IUPHAR Subcommittee on the kisspeptin receptor [9]), like neuropeptide FF (NPFF), prolactin-releasing peptide (PrP) and QRFP receptors (provisional nomenclature) responds to endogenous peptides with an arginine-phenylalanine-amide (RFamide) motif. kisspeptin-54 (KP54, originally named metastin), kisspeptin-13 (KP13) and kisspeptin-10 (KP10) are biologically-active peptides cleaved from the KISS1 (Q15726) gene product. Kisspeptins have roles in, for example, cancer metastasis, fertility/puberty regulation and glucose homeostasis.