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Elsevier, European Journal of Pharmacology, 2-3(221), p. 403-404

DOI: 10.1016/0014-2999(92)90734-l

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Marked decrease of A10 dopamine neuronal firing during ethanol withdrawal syndrome in rats

Journal article published in 1992 by Marco Diana, Rossetti Zl, Marco Pistis, Annalisa Muntoni, Zvani L. Rossetti, GianLuigi Gessa, Gessa Gl
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

The electrophysiological activity of mesoaccumbens dopaminergic neurons was monitored during the ethanol-withdrawal syndrome in ethanol-dependent and in control rats. Spontaneous firing was reduced by about half in ethanol-dependent rats as compared to controls. Likewise, the number of spikes/burst was also reduced in ethanol-dependent rats. These results are consistent with the reduction in dopamine release observed during ethanol-withdrawal syndrome and may provide the basis for the aversive effects of the ethanol-withdrawal syndrome.