Published in
American Association for the Advancement of Science, Science Translational Medicine, 563(12), 2020
DOI: 10.1126/scitranslmed.aaz2541
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Aβ-accelerated neurodegeneration caused by Alzheimer’s-associated ACE variant R1279Q is rescued by angiotensin system inhibition in mice
Journal article published in 2020 by
Leah K. Cuddy 
,
Dmitry Prokopenko ,
Eric P. Cunningham ,
Ross Brimberry,
Peter Song ,
Rory Kirchner ,
Brad A. Chapman,
Oliver Hofmann ,
Winston Hide ,
Daniele Procissi ,
Taleen Hanania ,
Steven C. Leiser,
Rudolph E. Tanzi ,
Robert Vassar
,
Dmitry Prokopenko ,
Eric P. Cunningham ,
Ross Brimberry,
Peter Song ,
Rory Kirchner ,
Brad A. Chapman,
Oliver Hofmann ,
Winston Hide ,
Daniele Procissi ,
Taleen Hanania ,
Steven C. Leiser,
Rudolph E. Tanzi ,
Robert Vassar
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Abstract
Ace1 knockin mice have increased neuronal ACE1 and hippocampal neuron loss that is accelerated by Aβ and blocked by approved angiotensin pathway drugs.