Numerous pesticide policies have been introduced to mitigate the risks of pesticide use, but most have not been successful in reaching usage reduction goals. Here, we name key challenges for the reduction of environmental and health risks from agricultural pesticide use and develop a framework for improving current policies. We demonstrate the need for policies to encompass all actors in the food value chain. By adopting a multi-disciplinary approach, we suggest ten key steps to achieve a reduction in pesticide risks. We highlight how new technologies and regulatory frameworks can be implemented and aligned with all actors in food value chains. Finally, we discuss major trade-offs and areas of tension with other agricultural policy goals and propose a holistic approach to advancing pesticide policies.