Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 12(64), 2020
DOI: 10.1128/aac.00807-20
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Gallic and Ellagic Acids Are Promising Adjuvants to Conventional Amphotericin B for the Treatment of Cutaneous Leishmaniasis
,
Daniel Dias Rufino Arcanjo ,
Kayo Alves Figueiredo,
Jéssica Sara de Sousa Macêdo Oliveira,
Felipe José Costa Viana,
Elvilene de Sousa Coelho,
Glaucia Lais Nunes Lopes,
Juan Carlos Ramos Gonçalves ,
André Luís Menezes Carvalho,
Márcia dos Santos Rizzo ,
Mariana Helena Chaves,
Ivete Lopes de Mendonça,
Fernando Aécio de Amorim Carvalho
Full text: Unavailable
Abstract
In this study, we demonstrated the potential associative effect of combining conventional amphotericin B (Amph B) with gallic acid (GA) and with ellagic acid (EA) in topical formulations for the treatment of cutaneous leishmaniasis in BALB/c mice. Preliminary stability tests of the formulations and in vitro drug release studies with Amph B, GA, Amph B plus GA, EA, and Amph B plus EA were carried out, as well as assessment of the in vivo treatment of BALB/c mice infected with Leishmania major .