We reported the growth of Fe2As single crystals and the study of its physical properties via comprehensive measurements, such as transport properties under pressure and high-pressure synchrotron radiation X-ray diffraction. Fe2As is an antiferromagnetic metal with TN ~ 355 K. Within the pressure range of 100 GPa, no superconductivity was observed above 2 K. The abrupt drop in resistance from 21 to 31.7 GPa suggests a high-pressure phase transition happens. The high-pressure X-ray experiments indicate a new high-pressure phase appears, starting from 27.13 GPa. After the refinement of the high-pressure X-ray data, the pressure dependence of lattice constants of Fe2As (P4/nmm phase) was plotted and the bulk modulus B0 was obtained to be 168.6 GPa.