Abstract Background: The risk factors of female lung cancer in China are still unclear. The growing trend of lung cancer in Chinese women has become a global concern of public health. This study aims to explore the secular trends and regional distribution of female lung cancer in China. Method: The results of global burden of disease (GBD 2016) and the world standard population database (WHO 2000-2025) were used to extract age- sex- and province-specific incidence, mortality, and years of life lost due to premature death (YLL) for this report. The Joinpoint regression analysis was applied to fit the secular female lung cancer trends of age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), and YLL rate for China and its 33 provincial administrative regions in 1992-2016. Result: From 1992 to 2016, the secular trend of female lung cancer incidence in China rose upward and the trend of mortality or rate of YLL fell down. The average annual percent change (AAPC) of the ASIR, ASMR, and YLL rate were 0.7 (95%CI: 0.6,0.8%), -0.3% (95%CI: -0.5, -0.2%), and -0.7 (95%CI: -0.8, -0.6%) respectively. However, the secular trends among 33 provincial units are inconsistent. There were 5 regional patterns of joint trends in ASIR, ASMR, and YLL rate among 33 provinces, autonomous regions, and municipalities. Conclusion: The regional pattern of the trends of female lung cancer in China suggested that the prevention and control of female lung cancer should be taken with targeted regional interventions. Citation Format: Xue Ni, Bei Zhang, Ning Xu, Xinying Zeng, Qiang Wang. Trends and regional distribution pattern of female lung cancer in China from 1992 to 2016 [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 5761.